New Research Article: Dr Annika Winbo
We present the first study of patient-derived LQT1 sympathetic neurons that are norepinephrine secreting, and electrophysiologically functional, in vitro. Our data reveal a novel LQT1 sympathetic neuronal phenotype of increased neurotransmission and excitability. The identified sympathetic neuronal hyperactivity phenotype is of particular relevance as it could contribute to the mechanisms underlying sympathetically triggered arrhythmia in LQT1.
PDF available to read: Functional hyperactivity in long QT syndrome type 1 pluripotent stem cell-derived sympathetic neurons – in American Journal of Physiology-Heart and Circulatory Physiology
Reference: Winbo A, Ramanan S, Eugster E, Rydberg A, Jovinge S, Skinner JR, Montgomery JM. Functional Hyperactivity in Long QT Syndrome Type 1 Pluripotent Stem Cell-Derived Sympathetic Neurons. Am J Physiol Heart Circ Physiol. 2021 Jun 18. doi: 10.1152/ajpheart.01002.2020.